RIN2

Across TCGA patient cohorts, RIN2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIN2-associated genes across cancer lineages are Fibronectin, NF2, and PCNA. Each is linked with RIN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIN2-to-partner and partner-to-RIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by RIN2-low versus RIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIN2→partner) and Y-score (partner→RIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.271	-1.415	.028	.046	3	2
UCEC	NF2 →	+0.167	+1.415	.039	.046	3	2
UCEC	PCNA →	+0.199	+1.415	.014	.046	3	2
UCEC	Shc_pY317 →	-0.153	-2.700	.007	.006	3	2
UCEC	ATM →	-0.532	-2.794	.001	.002	3	2
UCEC	C-Raf →	+0.124	+1.700	.021	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Fibronectin by RIN2 expression — UCEC

Explore this box plot interactively →