RIN2

Across TCGA pan-cancer cohorts, RIN2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated RIN2 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RIN2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RIN2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUAD show a favorable association.

KIRC, OV, and LUAD are the cancer types where RIN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.758	0.513	<.001	98	view →
OV	OS	Tertile	All	0.238	0.376	<.001	64	view →
LUAD	DFS	Median	III,IV	0.702	0.308	<.001	54	view →
LGG	DFS	Tertile	All	0.501	0.351	<.001	36	view →
BLCA	DFS	Tertile	All	0.172	0.542	.006	22	view →
PAAD	OS	Tertile	All	0.635	0.446	.028	17	view →
THCA	DFS	Median	All	0.918	0.714	.007	16	view →
PRAD	DFS	Median	All	0.918	0.853	.016	16	view →
COAD	DFS	Tertile	All	0.323	0.590	.013	15	view →
MESO	OS	Median	II,III,IV	0.198	0.380	.005	15	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	14	view →
UVM	DFS	Quartile	III,IV	0.242	1.000	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

RIN2–KIRC (OS)

Open the KIRC breakdown →