RIN2

Across TCGA cell cohorts, RIN2 mutation is significantly associated with the RNA expression of many other genes, with 109 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible RIN2-associated genes across cancer lineages are IQCF5, OR5W2, and PYDC2. Each is linked with RIN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RIN2-to-partner and partner-to-RIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by RIN2-low versus RIN2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIN2→partner) and Y-score (partner→RIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.042	+4.357	<.001	.006	3	3
UPPER_AERODIGESTIVE_TRACT	OR5W2 →	+0.042	+4.357	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	PYDC2 →	+0.095	+4.357	<.001	.006	3	2
SKIN	FCN1 →	+0.046	+4.273	<.001	.006	3	2
OVARY	PPY →	+0.241	+4.029	<.001	.009	3	2
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 109 associations by consensus.

IQCF5 by RIN2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →