RIN1

Across TCGA pan-cancer cohorts, RIN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RIN1 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RIN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RIN1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

CCRCC, UCEC, and LSCC are the cancer types where RIN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.424	0.816	.010	23	view →
UCEC	OS	Median	All	0.966	0.859	.032	10	view →
LSCC	OS	Median	II,III,IV	0.805	0.912	.025	6	view →
PDAC	DFS	Quartile	All	0.539	0.357	.045	2	view →
LUAD	OS	Tertile	III,IV	0.168	0.770	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RIN1–CCRCC (OS)

Open the CCRCC breakdown →