RIN1

Across TCGA patient cohorts, RIN1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIN1-associated genes across cancer lineages are IGFBP2, MEK1, and p62 Lck ligand. Each is linked with RIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIN1-to-partner and partner-to-RIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by RIN1-low versus RIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIN1→partner) and Y-score (partner→RIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.870	-2.906	<.001	.001	3	1
UCEC	MEK1 →	+0.452	+3.000	<.001	<.001	3	1
UCEC	p62 Lck ligand →	+0.355	+2.232	.003	.005	3	1
UCEC	P-Cadherin →	-0.112	-1.990	.038	.030	3	1
UCEC	Rad50 →	-0.320	-2.169	<.001	.003	3	1
UCEC	Annexin-1 →	+0.454	+2.479	.021	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

IGFBP2 by RIN1 expression — UCEC

Explore this box plot interactively →