RIN1

Across TCGA cell cohorts, RIN1 mutation is significantly associated with the RNA expression of many other genes, with 146 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RIN1-associated genes across cancer lineages are LORICRIN, TIMM44, and ACBD5. Each is linked with RIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIN1-to-partner and partner-to-RIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LORICRIN grouped by RIN1-low versus RIN1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIN1→partner) and Y-score (partner→RIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LORICRIN →	+0.029	+4.700	<.001	.002	3	1
LARGE_INTESTINE	TIMM44 →	+0.687	+3.212	.002	.006	3	1
LARGE_INTESTINE	ACBD5 →	+0.921	+3.212	<.001	.006	3	1
LARGE_INTESTINE	DPH1 →	+0.690	+3.212	.006	.006	3	1
LARGE_INTESTINE	CRACD →	+0.938	+3.212	.009	.006	3	1
LARGE_INTESTINE	HINT3 →	+0.822	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 146 associations by consensus.

LORICRIN by RIN1 expression — OVARY

Explore this box plot interactively →