RIMS4

Across TCGA cell cohorts, RIMS4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RIMS4-associated genes across cancer lineages are USP17L11, USP17L17, and USP17L20. Each is linked with RIMS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIMS4-to-partner and partner-to-RIMS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L11 grouped by RIMS4-low versus RIMS4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIMS4→partner) and Y-score (partner→RIMS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	USP17L11 →	+0.012	+4.415	<.001	.007	3	1
SKIN	USP17L17 →	+0.010	+5.022	<.001	.002	3	1
SKIN	USP17L20 →	+0.012	+4.415	<.001	.007	3	1
SKIN	USP17L18 →	+0.012	+4.415	<.001	.007	3	1
SKIN	TCP11X1 →	+0.009	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	GPR42 →	+0.016	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

USP17L11 by RIMS4 expression — SKIN

Explore this box plot interactively →