RIMS3

Across TCGA patient cohorts, RIMS3 mutation is significantly associated with the RNA expression of many other genes, with 1,150 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIMS3-associated genes across cancer lineages are RNU6-1318P, SNORD116-16, and RTRAFP2. Each is linked with RIMS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIMS3-to-partner and partner-to-RIMS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1318P grouped by RIMS3-low versus RIMS3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIMS3→partner) and Y-score (partner→RIMS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-1318P →	+0.212	+3.069	<.001	.009	3	2
SKCM	SNORD116-16 →	+0.433	+2.915	.002	.002	3	2
SKCM	RTRAFP2 →	+0.077	+2.811	.006	.003	3	2
HNSC	RN7SL211P →	+0.172	+5.608	<.001	.002	3	2
UCEC	RNA5SP455 →	+0.141	+3.247	<.001	.003	3	2
UCEC	RNA5SP170 →	+0.078	+4.208	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,150 associations by consensus.

RNU6-1318P by RIMS3 expression — SKCM

Explore this box plot interactively →