RIMS1

Across TCGA pan-cancer cohorts, RIMS1 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated RIMS1 data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RIMS1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated RIMS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LIHC show a favorable association.

UCEC, MESO, and OV are the cancer types where RIMS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.955	0.293	<.001	36	view →
MESO	DFS	Median	II,III,IV	0.039	0.407	<.001	12	view →
OV	OS	Median	IV	0.059	0.759	.006	12	view →
CESC	OS	Median	IV	0.091	0.593	<.001	12	view →
SCLC	OS	Median	IV	0.164	0.647	.017	9	view →
HNSC	DFS	Median	II,III,IV	0.339	0.597	.033	8	view →
DLBC	DFS	Median	III,IV	0.137	0.790	<.001	6	view →
KIRC	OS	Median	All	0.263	0.810	.015	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SARC	DFS	Median	All	0.069	0.632	<.001	6	view →
READ	DFS	Median	IV	0.255	0.628	.020	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

RIMS1–UCEC (DFS)

Open the UCEC breakdown →