RIMKLA

Across TCGA cell cohorts, RIMKLA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,505 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RIMKLA-associated GO terms across cancer lineages are Positive regulation of complement activation, Regulation of glycogen metabolic process, and Formation of primary germ layer. Each is linked with RIMKLA in more than 7 cancer types. Because this analysis shows association rather than direction, both RIMKLA-to-partner and partner-to-RIMKLA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of complement activation grouped by RIMKLA-low versus RIMKLA-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RIMKLA→partner) and Y-score (partner→RIMKLA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of complement activation →	-1.816	-0.913	<.001	.001	3	8
LUNG_SCLC	Regulation of glycogen metabolic process →	+0.062	+1.425	.001	.003	3	8
LUNG_SCLC	Formation of primary germ layer →	-0.053	-1.035	.003	.006	3	8
LUNG_SCLC	Tetrahydrobiopterin biosynthetic process →	+0.172	+2.046	<.001	<.001	3	7
URINARY_TRACT	Positive regulation of glycogen metabolic process →	+0.073	+0.685	.003	.008	3	7
LARGE_INTESTINE	Copper ion export →	-0.185	-0.721	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,505 associations by consensus.

Positive regulation of complement activation by RIMKLA expression — BREAST

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