RILP

Across TCGA cell cohorts, RILP mutation is significantly associated with the mutation status of many other genes, with 922 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RILP-associated genes across cancer lineages are RIPOR1, SARM1, and CYBA. Each is linked with RILP in more than 1 cancer types. Because this analysis shows association rather than direction, both RILP-to-partner and partner-to-RILP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIPOR1 grouped by RILP-low versus RILP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RILP→partner) and Y-score (partner→RILP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RIPOR1 →	+2.781	+4.504	<.001	<.001	1	2
LARGE_INTESTINE	SARM1 →	+3.459	+4.000	<.001	<.001	1	2
LARGE_INTESTINE	CYBA →	+3.459	+3.459	.006	.006	1	2
LARGE_INTESTINE	YIPF1 →	+4.044	+3.744	.003	.003	1	2
LARGE_INTESTINE	TARBP1 →	+2.874	+3.632	.002	.002	1	2
LARGE_INTESTINE	ADAT1 →	+4.044	+3.744	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 922 associations by consensus.

RIPOR1 by RILP expression — LARGE_INTESTINE

Explore this box plot interactively →