RIF1

Across TCGA pan-cancer cohorts, RIF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RIF1 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RIF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RIF1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where RIF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.300	0.808	<.001	78	view →
HNSC	OS	Median	All	0.380	1.000	.008	15	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	6	view →
LUAD	DFS	Median	II,III,IV	1.000	0.798	.015	6	view →
LSCC	DFS	Median	II,III,IV	0.814	0.588	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RIF1–CCRCC (DFS)

Open the CCRCC breakdown →