RIF1

Across TCGA pan-cancer cohorts, RIF1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RIF1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RIF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RIF1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, STAD, and KIRP are the cancer types where RIF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RIF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.980	<.001	12	view →
STAD	Male	II,III,IV	+1.040	<.001	9	view →
KIRP	All	IV	+1.340	.001	8	view →
LIHC	All	II,III,IV	+0.762	<.001	8	view →
THCA	All	II,III,IV	−0.736	<.001	8	view →
BLCA	All	All	+0.561	.001	8	view →
KIRC	All	All	+0.438	<.001	8	view →
CHOL	Male	All	+2.015	<.001	5	view →
KICH	Female	All	−1.056	<.001	5	view →
LUSC	Male	II,III,IV	+0.827	<.001	5	view →
LUAD	Male	All	+0.734	<.001	5	view →
COAD	Male	All	+0.596	.003	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RIF1–HNSC

Open the HNSC breakdown →