RIF1

Across TCGA patient cohorts, RIF1 mutation is significantly associated with the RNA expression of many other genes, with 6,755 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIF1-associated genes across cancer lineages are NDUFS3, GINS4, and ENDOG. Each is linked with RIF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RIF1-to-partner and partner-to-RIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFS3 grouped by RIF1-low versus RIF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIF1→partner) and Y-score (partner→RIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFS3 →	+0.273	+1.791	<.001	<.001	3	5
UCEC	GINS4 →	+0.559	+1.349	<.001	<.001	3	5
UCEC	ENDOG →	+0.443	+1.438	<.001	.002	3	5
UCEC	UFD1 →	+0.369	+1.769	<.001	<.001	3	5
COAD	MCUB →	+0.914	+4.053	<.001	<.001	3	4
COAD	MIB2 →	+0.422	+1.805	.009	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,755 associations by consensus.

NDUFS3 by RIF1 expression — UCEC

Explore this box plot interactively →