RIF1

Across TCGA patient cohorts, RIF1 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIF1-associated genes across cancer lineages are eIF4E, STAT3_pY705, and ASNS. Each is linked with RIF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RIF1-to-partner and partner-to-RIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RIF1-low versus RIF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIF1→partner) and Y-score (partner→RIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.167	+2.676	.002	<.001	3	4
UCEC	STAT3_pY705 →	-0.244	-1.523	<.001	.005	3	4
UCEC	ASNS →	+0.292	+1.184	.002	.019	3	4
UCEC	c-Kit →	-0.137	-1.137	.024	.008	3	4
UCEC	PCNA →	+0.190	+1.428	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.540	+1.428	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

eIF4E by RIF1 expression — UCEC

Explore this box plot interactively →