RIF1

Across TCGA cell cohorts, RIF1 mutation is significantly associated with the RNA expression of many other genes, with 1,040 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RIF1-associated genes across cancer lineages are REG3G, TNP1, and CCDC83. Each is linked with RIF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIF1-to-partner and partner-to-RIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3G grouped by RIF1-low versus RIF1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIF1→partner) and Y-score (partner→RIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	REG3G →	+0.050	+3.906	<.001	.009	3	2
SOFT_TISSUE	TNP1 →	+1.110	+4.369	<.001	.008	3	2
LUNG_NSCLC_LUAD	CCDC83 →	+0.062	+4.115	<.001	.003	3	2
LUNG_NSCLC_LUAD	IL25 →	+0.007	+4.078	.003	.009	3	2
LARGE_INTESTINE	KCTD9 →	+0.818	+2.780	<.001	<.001	3	2
LARGE_INTESTINE	PIH1D1 →	+0.400	+2.000	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,040 associations by consensus.

REG3G by RIF1 expression — BLOOD_Myeloma

Explore this box plot interactively →