RICTOR

Across TCGA patient cohorts, RICTOR mutation is significantly associated with the RNA expression of many other genes, with 4,906 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RICTOR-associated genes across cancer lineages are NOLC1, HDHD5, and RANBP1. Each is linked with RICTOR in more than 3 cancer types. Because this analysis shows association rather than direction, both RICTOR-to-partner and partner-to-RICTOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOLC1 grouped by RICTOR-low versus RICTOR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RICTOR→partner) and Y-score (partner→RICTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NOLC1 →	+0.402	+2.343	.001	<.001	3	4
UCEC	HDHD5 →	+0.402	+1.860	<.001	<.001	3	4
SKCM	RANBP1 →	+0.451	+2.421	.003	.002	3	4
STAD	RPF1 →	+0.356	+2.940	.001	<.001	3	4
STAD	ECHS1 →	+0.522	+3.476	<.001	.002	3	4
SKCM	FBXO7 →	+0.559	+3.331	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,906 associations by consensus.

NOLC1 by RICTOR expression — UCEC

Explore this box plot interactively →