RICTOR

Across TCGA pan-cancer cohorts, RICTOR RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RICTOR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RICTOR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RICTOR is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, THCA, and UCEC are the cancer types where RICTOR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RICTOR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.669	<.001	9	view →
THCA	Male	All	−0.698	<.001	8	view →
UCEC	All	All	−1.213	<.001	6	view →
LIHC	All	All	+0.402	<.001	6	view →
CHOL	All	All	+1.593	<.001	5	view →
STAD	All	II,III,IV	+0.650	.014	3	view →
LUSC	Female	III,IV	−0.640	.022	2	view →
ESCA	All	All	+0.582	.007	2	view →
LUSC	Male	All	+0.338	.026	2	view →
LUAD	Male	All	+0.434	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

RICTOR–HNSC

Open the HNSC breakdown →