RICTOR

Across TCGA patient cohorts, RICTOR mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RICTOR-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and FASN. Each is linked with RICTOR in more than 2 cancer types. Because this analysis shows association rather than direction, both RICTOR-to-partner and partner-to-RICTOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RICTOR-low versus RICTOR-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RICTOR→partner) and Y-score (partner→RICTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+0.741	+3.000	.021	.034	3	3
UCEC	ATM →	-0.380	-2.074	.003	.004	3	3
STAD	FASN →	+0.427	+3.015	.018	.018	3	2
COAD	GAPDH →	+0.543	+3.008	.039	.019	3	2
STAD	PKC-delta_pS664 →	-0.123	-2.984	.036	.034	3	2
UCEC	Cyclin-B1 →	+0.736	+3.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Caspase-7-cleavedD198 by RICTOR expression — STAD

Explore this box plot interactively →