RICTOR

Across TCGA cell cohorts, RICTOR mutation is significantly associated with the RNA expression of many other genes, with 305 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RICTOR-associated genes across cancer lineages are BPIFA1, MRAP, and IFNA6. Each is linked with RICTOR in more than 1 cancer types. Because this analysis shows association rather than direction, both RICTOR-to-partner and partner-to-RICTOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFA1 grouped by RICTOR-low versus RICTOR-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RICTOR→partner) and Y-score (partner→RICTOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	BPIFA1 →	+0.136	+4.906	<.001	.006	3	2
UPPER_AERODIGESTIVE_TRACT	MRAP →	+0.028	+4.736	<.001	.009	3	2
BLOOD_Leukemia	IFNA6 →	+0.214	+3.475	<.001	.006	3	2
BLOOD_Leukemia	SPIC →	+1.310	+3.684	<.001	.004	3	2
BLOOD_Leukemia	TRIM49B →	+0.094	+4.289	<.001	<.001	3	2
LUNG_NSCLC_LUSC	KRTAP13-2 →	+0.229	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 305 associations by consensus.

BPIFA1 by RICTOR expression — OESOPHAGUS

Explore this box plot interactively →