RIC8B

Across TCGA pan-cancer cohorts, RIC8B Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RIC8B data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher RIC8B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RIC8B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, SKCM, and LUAD are the cancer types where RIC8B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.144	0.740	<.001	30	view →
SKCM	DFS	Median	All	0.218	0.624	<.001	27	view →
LUAD	OS	Median	All	0.111	0.835	<.001	24	view →
HNSC	OS	Median	IV	0.189	0.736	<.001	23	view →
UCEC	DFS	Median	All	0.819	0.629	.014	16	view →
ESCA	DFS	Median	All	0.075	0.533	<.001	12	view →
COAD	DFS	Median	All	0.212	0.696	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RIC8B–CESC (DFS)

Open the CESC breakdown →