RIC8B

Across TCGA pan-cancer cohorts, RIC8B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RIC8B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RIC8B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RIC8B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where RIC8B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RIC8B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.758	<.001	12	view →
THCA	Male	III,IV	−1.442	<.001	11	view →
LIHC	All	All	+0.594	<.001	9	view →
KICH	Female	All	−1.076	<.001	8	view →
COAD	All	II,III,IV	+0.257	.001	6	view →
UCEC	All	All	−0.736	<.001	4	view →
STAD	All	II,III,IV	+0.638	.003	4	view →
CHOL	All	All	+2.143	<.001	3	view →
LUAD	Female	II,III,IV	−0.496	<.001	3	view →
BLCA	Male	IV	−0.832	.008	2	view →
ESCA	All	All	+0.700	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RIC8B–HNSC

Open the HNSC breakdown →