RIC8B

Across TCGA pan-cancer cohorts, RIC8B mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RIC8B data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RIC8B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RIC8B expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

COAD, LSCC, and CCRCC are the cancer types where RIC8B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.827	1.000	.038	18	view →
LSCC	DFS	Median	All	0.975	0.903	.007	5	view →
CCRCC	OS	Quartile	All	0.759	0.946	.028	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

RIC8B–COAD (DFS)

Open the COAD breakdown →