RIC8B

Across TCGA patient cohorts, RIC8B mutation is significantly associated with the RNA expression of many other genes, with 3,793 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIC8B-associated genes across cancer lineages are RNA5SP412, MTATP6P21, and RNA5SP497. Each is linked with RIC8B in more than 1 cancer types. Because this analysis shows association rather than direction, both RIC8B-to-partner and partner-to-RIC8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by RIC8B-low versus RIC8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIC8B→partner) and Y-score (partner→RIC8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.599	+2.189	<.001	<.001	3	2
HNSC	MTATP6P21 →	+0.326	+4.826	<.001	.001	3	2
HNSC	RNA5SP497 →	+0.284	+5.178	<.001	.002	3	2
BLCA	RNU6-710P →	+0.185	+4.147	<.001	.009	3	2
UCEC	RNA5SP421 →	+0.614	+1.826	<.001	<.001	3	2
UCEC	TRGJP2 →	+0.285	+1.403	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,793 associations by consensus.

RNA5SP412 by RIC8B expression — UCEC

Explore this box plot interactively →