RIC8B

Across TCGA patient cohorts, RIC8B mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RIC8B-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1068, and eIF4E. Each is linked with RIC8B in more than 1 cancer types. Because this analysis shows association rather than direction, both RIC8B-to-partner and partner-to-RIC8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by RIC8B-low versus RIC8B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIC8B→partner) and Y-score (partner→RIC8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.355	+2.169	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.208	-2.169	.007	.003	3	1
UCEC	eIF4E →	+0.140	+1.643	.032	.003	3	1
UCEC	ERK2 →	+0.126	+1.201	.034	.028	3	1
UCEC	ACC1 →	+0.384	+1.201	<.001	.028	3	1
UCEC	HER3_pY1289 →	+0.057	+1.785	.033	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

p62 Lck ligand by RIC8B expression — UCEC

Explore this box plot interactively →