RIC8B

Across TCGA cell cohorts, RIC8B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible RIC8B-associated genes across cancer lineages are CABP5, REG3A, and EDDM3B. Each is linked with RIC8B in more than 1 cancer types. Because this analysis shows association rather than direction, both RIC8B-to-partner and partner-to-RIC8B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CABP5 grouped by RIC8B-low versus RIC8B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIC8B→partner) and Y-score (partner→RIC8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CABP5 →	+0.016	+4.867	<.001	.009	3	1
BREAST	REG3A →	+0.028	+4.421	.001	.004	3	1
BREAST	EDDM3B →	+0.032	+4.672	<.001	.002	3	1
BREAST	LIPN →	+0.021	+4.963	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CABP5 by RIC8B expression — BLOOD_Lymphoma

Explore this box plot interactively →