RIC3

Across TCGA cell cohorts, RIC3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RIC3-associated genes across cancer lineages are PRR23B, OR4E2, and CRYGB. Each is linked with RIC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RIC3-to-partner and partner-to-RIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23B grouped by RIC3-low versus RIC3-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RIC3→partner) and Y-score (partner→RIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRR23B →	+0.010	+4.285	<.001	.007	3	2
OESOPHAGUS	OR4E2 →	+0.133	+4.906	<.001	.006	3	1
SKIN	CRYGB →	+0.039	+3.684	<.001	.006	3	1
SKIN	KIR3DL3 →	+0.004	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	PRM2 →	+0.028	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.013	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PRR23B by RIC3 expression — STOMACH

Explore this box plot interactively →