RIC3-DT

Across TCGA pan-cancer cohorts, RIC3-DT RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RIC3-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RIC3-DT RNA is repressed in tumor relative to normal tissue. In most cancer types RIC3-DT is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and UCEC are the cancer types where RIC3-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RIC3-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.013	<.001	7	view →
KICH	Male	All	−0.039	.014	5	view →
UCEC	All	II,III,IV	−0.027	.011	4	view →
THCA	All	All	−0.008	.004	3	view →
LUAD	Male	All	−0.010	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RIC3-DT–KIRC

Open the KIRC breakdown →