RHOU

Across TCGA patient cohorts, RHOU mutation is significantly associated with the RNA expression of many other genes, with 355 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOU-associated genes across cancer lineages are SIGLEC8, LINC01072, and RNU6-686P. Each is linked with RHOU in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOU-to-partner and partner-to-RHOU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC8 grouped by RHOU-low versus RHOU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOU→partner) and Y-score (partner→RHOU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SIGLEC8 →	+0.567	+3.459	.002	.005	3	2
UCEC	LINC01072 →	+0.167	+3.003	<.001	.001	3	2
COAD	RNU6-686P →	+0.528	+5.435	<.001	.005	3	2
SKCM	OR2B7P →	+0.068	+2.936	<.001	.005	3	1
SKCM	RNU6-527P →	+0.268	+3.625	<.001	.004	3	1
SKCM	TRBV10-1 →	+0.433	+3.698	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 355 associations by consensus.

SIGLEC8 by RHOU expression — UCEC

Explore this box plot interactively →