RHOQ

Across TCGA patient cohorts, RHOQ mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOQ-associated genes across cancer lineages are MEK1, ERK2, and FOXO3a_pS318_S321. Each is linked with RHOQ in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOQ-to-partner and partner-to-RHOQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RHOQ-low versus RHOQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOQ→partner) and Y-score (partner→RHOQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.394	+2.115	.013	.019	3	2
UCEC	ERK2 →	+0.253	+2.115	.002	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.136	-3.449	.012	.005	3	1
UCEC	mTOR_pS2448 →	-0.181	-3.302	.005	.010	3	1
UCEC	Notch1 →	+0.202	+2.331	.001	.019	3	1
UCEC	p62 Lck ligand →	+0.488	+3.179	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MEK1 by RHOQ expression — UCEC

Explore this box plot interactively →