RHOH

Across TCGA patient cohorts, RHOH protein abundance is significantly associated with the RNA expression of many other genes, with 11,503 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RHOH-associated genes across cancer lineages are DOK4, METTL9, and IGHV1-2. Each is linked with RHOH in more than 2 cancer types. Because this analysis shows association rather than direction, both RHOH-to-partner and partner-to-RHOH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RHOH versus DOK4 in HNSC, with a Pearson correlation of -0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOH→partner) and Y-score (partner→RHOH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DOK4 →	-0.662	-1.050	.003	.001	3	3
LSCC	METTL9 →	-0.423	-0.811	<.001	<.001	3	3
LUAD	IGHV1-2 →	+1.470	+0.623	<.001	<.001	3	3
LUAD	OCRL →	-0.478	-0.810	<.001	<.001	3	3
PDAC	NUMA1 →	-0.303	-0.467	.003	.006	3	3
LUAD	VKORC1L1 →	-0.576	-0.647	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,503 associations by consensus.

RHOH vs DOK4 — HNSC

Explore this scatter interactively →