RHOH

Across TCGA patient cohorts, RHOH mutation is significantly associated with the RNA expression of many other genes, with 1,044 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOH-associated genes across cancer lineages are LONRF2P2, MIR7702, and RNU6-362P. Each is linked with RHOH in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOH-to-partner and partner-to-RHOH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LONRF2P2 grouped by RHOH-low versus RHOH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOH→partner) and Y-score (partner→RHOH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LONRF2P2 →	+0.042	+5.412	<.001	.001	3	2
UCEC	MIR7702 →	+0.202	+4.060	<.001	.006	3	2
HNSC	RNU6-362P →	+0.368	+7.954	<.001	.008	3	2
SKCM	NDUFAF5 →	+0.554	+2.706	<.001	.003	3	2
UCEC	RBBP8 →	+0.644	+2.823	.006	.001	3	2
UCEC	CDADC1 →	+0.406	+3.625	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,044 associations by consensus.

LONRF2P2 by RHOH expression — COAD

Explore this box plot interactively →