RHOF

Across TCGA patient cohorts, RHOF mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible RHOF-associated genes across cancer lineages are CTBP2P3, SNORD90, and RNU6-163P. Each is linked with RHOF in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOF-to-partner and partner-to-RHOF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTBP2P3 grouped by RHOF-low versus RHOF-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOF→partner) and Y-score (partner→RHOF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CTBP2P3 →	+0.037	+3.623	<.001	.006	3	2
UCEC	SNORD90 →	+0.413	+2.670	<.001	.009	3	2
SKCM	RNU6-163P →	+0.286	+4.159	<.001	.002	3	2
UCEC	C1orf52 →	+0.503	+3.202	.004	.009	3	1
UCEC	TRIM49 →	+0.257	+2.646	.006	.004	3	1
UCEC	TCEANC →	+0.524	+3.234	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

CTBP2P3 by RHOF expression — SKCM

Explore this box plot interactively →