RHOC

Across TCGA pan-cancer cohorts, RHOC mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RHOC data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RHOC mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RHOC expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where RHOC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.922	0.645	<.001	35	view →
PDAC	OS	Median	II,III,IV	0.467	0.272	.003	25	view →
UCEC	DFS	Tertile	All	0.910	1.000	.042	2	view →
LSCC	OS	Tertile	III,IV	0.559	0.918	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RHOC–HNSC (DFS)

Open the HNSC breakdown →