RHOC

Across TCGA pan-cancer cohorts, RHOC RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RHOC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RHOC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RHOC is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where RHOC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RHOC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.428	<.001	12	view →
KIRC	Female	All	+0.597	<.001	11	view →
COAD	Female	II,III,IV	−0.839	<.001	10	view →
KICH	Female	II,III,IV	−2.154	<.001	9	view →
LIHC	Female	II,III,IV	+1.699	<.001	9	view →
THCA	Male	All	+0.558	<.001	8	view →
BRCA	Female	All	+0.381	<.001	6	view →
READ	All	All	−0.817	.001	5	view →
ESCA	All	All	+1.447	.007	4	view →
LUAD	All	II,III,IV	+0.517	.004	4	view →
CHOL	All	All	+2.508	<.001	3	view →
STAD	Male	II,III,IV	+0.641	.024	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RHOC–HNSC

Open the HNSC breakdown →