RHOC

Across TCGA patient cohorts, RHOC RNA expression is significantly associated with the protein abundance of many other proteins, with 11,388 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RHOC-associated proteins across cancer lineages are TNKS1BP1, USP39, and PXN. Each is linked with RHOC in more than 5 cancer types. Because this analysis shows association rather than direction, both RHOC-to-partner and partner-to-RHOC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RHOC versus TNKS1BP1 in GBM, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOC→partner) and Y-score (partner→RHOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNKS1BP1 →	+0.363	+0.396	<.001	.002	3	6
LSCC	USP39 →	-0.294	-0.494	<.001	<.001	3	5
LSCC	PXN →	+0.397	+0.682	<.001	<.001	3	5
OV	FAM114A1 →	+0.472	+0.618	<.001	.001	3	5
OV	BCAR1 →	+0.408	+0.647	.001	.002	3	5
BRCA	TRIO →	+0.305	+0.748	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,388 associations by consensus.

RHOC vs TNKS1BP1 — GBM

Explore this scatter interactively →