RHOC

Across TCGA patient cohorts, RHOC mutation is significantly associated with the RNA expression of many other genes, with 163 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOC-associated genes across cancer lineages are RPL34P3, MORF4L1P7, and RNA5SP422. Each is linked with RHOC in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOC-to-partner and partner-to-RHOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL34P3 grouped by RHOC-low versus RHOC-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOC→partner) and Y-score (partner→RHOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL34P3 →	+0.196	+5.378	<.001	.006	3	2
OV	MORF4L1P7 →	+0.084	+6.333	<.001	.001	3	2
UCEC	RNA5SP422 →	+1.167	+3.256	<.001	<.001	3	2
BRCA	RN7SL386P →	+0.276	+7.234	<.001	<.001	3	1
BRCA	MIR548O2 →	+0.685	+5.378	<.001	.006	3	1
BRCA	OR5AP2 →	+0.044	+6.442	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 163 associations by consensus.

RPL34P3 by RHOC expression — BRCA

Explore this box plot interactively →