RHOC

Across TCGA patient cohorts, RHOC mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOC-associated genes across cancer lineages are FOXO3a, p62 Lck ligand, and Rad50. Each is linked with RHOC in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOC-to-partner and partner-to-RHOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by RHOC-low versus RHOC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOC→partner) and Y-score (partner→RHOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	-0.137	-2.986	.019	.037	1	1
UCEC	p62 Lck ligand →	+0.418	+3.000	.026	.037	1	1
UCEC	Rad50 →	-0.355	-3.000	.011	.037	1	1
UCEC	Caspase-7-cleavedD198 →	+0.802	+3.000	.019	.037	1	1
UCEC	4E-BP1 →	+0.488	+3.000	.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FOXO3a by RHOC expression — UCEC

Explore this box plot interactively →