RHOC

Across TCGA cell cohorts, RHOC RNA expression is significantly associated with the go_rna of many other GO terms, with 6,264 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RHOC-associated GO terms across cancer lineages are Positive regulation of cell-matrix adhesion, Positive regulation of cytoskeleton organization, and Regulation of cell-substrate adhesion. Each is linked with RHOC in more than 14 cancer types. Because this analysis shows association rather than direction, both RHOC-to-partner and partner-to-RHOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell-matrix adhesion grouped by RHOC-low versus RHOC-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOC→partner) and Y-score (partner→RHOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of cell-matrix adhesion →	+0.167	+1.814	<.001	<.001	3	15
LIVER	Positive regulation of cytoskeleton organization →	+0.106	+1.950	<.001	<.001	3	13
BONE	Regulation of cell-substrate adhesion →	+0.121	+1.937	<.001	<.001	3	13
BONE	Positive regulation of cell-substrate adhesion →	+0.146	+1.705	<.001	<.001	3	13
BONE	Positive regulation of actin filament bundle assembly →	+0.195	+1.889	<.001	<.001	3	13
LIVER	Positive regulation of canonical NF-kappaB signal transduction →	+0.070	+1.443	.001	.004	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,264 associations by consensus.

Positive regulation of cell-matrix adhesion by RHOC expression — BONE

Explore this box plot interactively →