RHOA

Across TCGA pan-cancer cohorts, RHOA mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated RHOA data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RHOA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RHOA expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

COAD, HNSC, and GBM are the cancer types where RHOA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.879	1.000	.018	36	view →
HNSC	OS	Tertile	IV	0.968	0.706	.009	23	view →
GBM	DFS	Quartile	All	0.847	0.586	.001	17	view →
LUAD	OS	Quartile	III,IV	0.508	0.996	.003	9	view →
PDAC	DFS	Tertile	III,IV	0.237	0.623	.024	8	view →
CCRCC	OS	Median	II,III,IV	0.454	1.000	.014	6	view →
UCEC	DFS	Quartile	All	0.801	1.000	.027	4	view →
LSCC	DFS	Median	All	0.874	1.000	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

RHOA–COAD (DFS)

Open the COAD breakdown →