RHOA

Across TCGA pan-cancer cohorts, RHOA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RHOA’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RHOA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RHOA is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LIHC, LUSC, and KICH are the cancer types where RHOA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RHOA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	+1.141	<.001	9	view →
LUSC	All	III,IV	−0.941	<.001	8	view →
KICH	Female	All	−1.132	<.001	7	view →
LUAD	Female	II,III,IV	−0.520	<.001	7	view →
CHOL	Male	All	+1.743	<.001	5	view →
STAD	All	II,III,IV	+0.352	.012	3	view →
THCA	All	All	−0.160	.016	3	view →
UCEC	All	All	−0.574	.001	2	view →
KIRC	All	II,III,IV	−0.223	.014	2	view →
BRCA	Female	II,III,IV	+0.125	.031	2	view →
READ	Female	All	−0.466	.009	1	view →
COAD	Male	III,IV	+0.214	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RHOA–LIHC

Open the LIHC breakdown →