RHOA

Across TCGA patient cohorts, RHOA mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHOA-associated genes across cancer lineages are SCD, 4E-BP1, and p90 RSK. Each is linked with RHOA in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOA-to-partner and partner-to-RHOA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCD grouped by RHOA-low versus RHOA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOA→partner) and Y-score (partner→RHOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCD →	+0.100	+1.598	.020	.022	3	2
UCEC	4E-BP1 →	+0.298	+2.199	.005	.033	3	2
STAD	p90 RSK →	+0.335	+3.000	.010	.036	3	1
UCEC	eIF4E →	+0.167	+2.115	.044	.017	3	1
UCEC	eIF4G →	+0.248	+1.584	.042	.036	3	1
UCEC	FASN →	+0.325	+1.584	.036	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

SCD by RHOA expression — UCEC

Explore this box plot interactively →