RHOA

Across TCGA cell cohorts, RHOA mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RHOA-associated genes across cancer lineages are SLC2A7, CABP2, and CBLIF. Each is linked with RHOA in more than 1 cancer types. Because this analysis shows association rather than direction, both RHOA-to-partner and partner-to-RHOA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC2A7 grouped by RHOA-low versus RHOA-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHOA→partner) and Y-score (partner→RHOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SLC2A7 →	+0.013	+4.643	<.001	.008	3	1
BREAST	CABP2 →	+0.387	+5.169	<.001	.005	3	1
LARGE_INTESTINE	CBLIF →	+0.332	+3.519	<.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GP9 →	+0.067	+3.518	.003	.001	3	1
LARGE_INTESTINE	LCN8 →	+0.137	+3.125	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SLC2A7 by RHOA expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →