RHOA-IT1

Across TCGA pan-cancer cohorts, RHOA-IT1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RHOA-IT1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RHOA-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RHOA-IT1 expression acts as an unfavorable survival marker, although some lineages such as UCS and THYM show a favorable association.

COAD, THCA, and UCS are the cancer types where RHOA-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.714	0.860	.002	71	view →
THCA	OS	Tertile	All	0.979	1.000	.006	58	view →
UCS	OS	Median	II,III,IV	0.564	0.239	.006	56	view →
KIRC	DFS	Median	IV	0.225	0.472	.003	49	view →
ACC	OS	Tertile	All	0.365	0.813	<.001	40	view →
LGG	DFS	Quartile	All	0.661	0.830	<.001	27	view →
MESO	OS	Tertile	All	0.468	0.644	.009	26	view →
CESC	DFS	Tertile	III,IV	0.615	0.912	.005	20	view →
THYM	DFS	Quartile	II,III,IV	0.949	0.642	.007	15	view →
READ	OS	Quartile	II,III,IV	0.916	0.312	.006	14	view →
LUSC	DFS	Median	II,III,IV	0.647	0.784	.003	13	view →
BRCA	DFS	Tertile	III,IV	0.650	0.423	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RHOA-IT1–COAD (OS)

Open the COAD breakdown →