RHOA-IT1

Across TCGA pan-cancer cohorts, RHOA-IT1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RHOA-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RHOA-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RHOA-IT1 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

COAD, STAD, and READ are the cancer types where RHOA-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RHOA-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.442	<.001	8	view →
STAD	All	All	+0.485	.003	4	view →
READ	All	III,IV	+0.450	<.001	4	view →
KIRC	All	All	+0.203	<.001	4	view →
HNSC	Female	All	+0.193	.026	4	view →
CHOL	All	All	+0.574	.016	2	view →
UCEC	All	III,IV	+0.563	.012	2	view →
LUSC	All	All	−0.204	.033	2	view →
PRAD	All	All	+0.191	.013	2	view →
BLCA	Female	IV	+0.370	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RHOA-IT1–COAD

Open the COAD breakdown →