RHEX

Across TCGA patient cohorts, RHEX protein abundance is significantly associated with the RNA expression of many other genes, with 781 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RHEX-associated genes across cancer lineages are HIF1A, SYP, and HAS3. Each is linked with RHEX in more than 1 cancer types. Because this analysis shows association rather than direction, both RHEX-to-partner and partner-to-RHEX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RHEX versus HIF1A in LUAD, with a Pearson correlation of -0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHEX→partner) and Y-score (partner→RHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HIF1A →	-0.694	-0.563	.007	<.001	3	1
LUAD	SYP →	+0.539	+0.542	.002	<.001	3	1
LUAD	HAS3 →	+1.293	+0.343	.002	.006	3	1
LUAD	DHDH →	+1.698	+0.518	.001	.002	3	1
LUAD	TLE6 →	+0.625	+0.382	.007	.001	3	1
LUAD	AKT2 →	+0.415	+0.484	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 781 associations by consensus.

RHEX vs HIF1A — LUAD

Explore this scatter interactively →