RHEX

Across TCGA patient cohorts, RHEX mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RHEX-associated genes across cancer lineages are MEK1, 14-3-3_beta, and EGFR_pY1068. Each is linked with RHEX in more than 1 cancer types. Because this analysis shows association rather than direction, both RHEX-to-partner and partner-to-RHEX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RHEX-low versus RHEX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHEX→partner) and Y-score (partner→RHEX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.418	+2.459	.018	.020	3	2
UCEC	14-3-3_beta →	-0.143	-3.149	.003	.019	3	1
UCEC	EGFR_pY1068 →	-0.332	-3.321	.006	.010	3	1
UCEC	MSH2 →	-0.327	-2.295	.003	.033	3	1
UCEC	Bax →	+0.239	+2.999	.039	.035	3	1
UCEC	Bcl-2 →	-0.422	-2.432	.011	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MEK1 by RHEX expression — UCEC

Explore this box plot interactively →