RHEB

Across TCGA pan-cancer cohorts, RHEB mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RHEB data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RHEB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RHEB expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where RHEB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.574	1.000	<.001	76	view →
LSCC	OS	Median	All	0.793	1.000	.025	2	view →
LUAD	OS	Tertile	All	0.669	0.913	.046	2	view →
HNSC	DFS	Tertile	All	1.000	0.933	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RHEB–CCRCC (OS)

Open the CCRCC breakdown →