RHEB

Across TCGA patient cohorts, RHEB RNA expression is significantly associated with the protein abundance of many other proteins, with 13,129 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RHEB-associated proteins across cancer lineages are CUL1, TNPO3, and CDK5. Each is linked with RHEB in more than 7 cancer types. Because this analysis shows association rather than direction, both RHEB-to-partner and partner-to-RHEB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RHEB versus CUL1 in LSCC, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RHEB→partner) and Y-score (partner→RHEB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CUL1 →	+0.281	+0.613	<.001	<.001	3	8
BRCA	TNPO3 →	+0.395	+0.612	<.001	<.001	3	7
OV	CDK5 →	+0.377	+0.423	.003	.006	3	6
CCRCC	ESYT2 →	+0.253	+0.510	<.001	<.001	3	6
OV	UBE3C →	+0.331	+0.604	<.001	<.001	3	6
CCRCC	ARHGEF5 →	+0.390	+0.492	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,129 associations by consensus.

RHEB vs CUL1 — LSCC

Explore this scatter interactively →