RHEB

Across TCGA patient cohorts, RHEB protein abundance is significantly associated with the RNA expression of many other genes, with 13,100 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible RHEB-associated genes across cancer lineages are ACTR3B, NCAPG2, and ZNF767P. Each is linked with RHEB in more than 7 cancer types. Because this analysis shows association rather than direction, both RHEB-to-partner and partner-to-RHEB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RHEB versus ACTR3B in BRCA, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RHEB→partner) and Y-score (partner→RHEB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACTR3B →	+0.893	+0.411	<.001	<.001	3	8
LSCC	NCAPG2 →	+0.720	+0.253	<.001	<.001	3	8
OV	ZNF767P →	+0.662	+0.392	.005	<.001	3	7
OV	RBM28 →	+0.550	+0.360	.002	.001	3	7
HNSC	CDK5 →	+0.734	+0.455	<.001	<.001	3	7
UCEC	ATP6V0E2 →	+1.029	+0.530	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,100 associations by consensus.

RHEB vs ACTR3B — BRCA

Explore this scatter interactively →